INOs-IN-8

INOs-IN-8 (Compound 13h) is a potent and highly selective inhibitor of inducible nitric oxide synthase (iNOS), with an IC50 of 238 nM. It demonstrates significant neuroprotective effects against neuronal and endothelial cell damage induced by oxygen-glucose deprivation/reoxygenation (OGD/R) and hydrogen peroxide. In rat models, iNOs-IN-8 significantly reduces infarct volume and improves neurological function. It is used in ischemic stroke research.