Cot-IN-4

Cot-IN-4 (compound 32) is a potent inhibitor of cancer Osaka thyroid (COT) kinase, with an IC50 value of 6 nM. It effectively inhibits the phosphorylation of ERK (IC50: 60 nM) and suppresses the release of TNFα (IC50: 60 nM) . Additionally, Cot-IN-4 reduces the production of the pro-inflammatory cytokine IL-1β in macrophages stimulated by uric acid (IC50: 0.2 μM) . This compound is applicable for research in inflammatory diseases.