PDE2-IN-1

PDE2-IN-1 is a potent and orally active inhibitor of PDE2 with an IC50 of 0.6 μM, exhibiting neuroprotective properties. It regulates the PKA/CREB/BDNF signaling pathway by inhibiting PDE2. PDE2-IN-1 can improve memory deficits and cognitive impairments in okadai acid (OKA) -induced Alzheimer's disease (AD) mouse models and is useful for Alzheimer's disease research.