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Kahalalide F

Kahalalide F is a novel marine-derived antitumor agent known for inhibiting DNA synthesis. It exhibits cytotoxicity that is not correlated with the expression levels of the multidrug resistance gene MDR1 or the tyrosine kinase HER2/NEU, and is only slightly related to the expression of the anti-apoptotic protein BCL-2. Kahalalide F hinders the PI3K-Akt signaling pathway by depleting ErbB3. Its effects are rapidly activated with short pulse treatments. The compound primarily induces cell death through oncosis (cellular swelling) in tumor cells. Kahalalide F can be utilized in studies of prostate cancer, breast cancer, vulvar cancer, and non-small cell lung cancer.

Product Specifications

CAS Number

149204-42-2

Smiles

C ([C@H] (NC ([C@@H] (NC ([C@@H] (NC ([C@H] (NC (CCCC (C) C) =O) [C@@H] (C) C) =O) [C@@H] (C) O) =O) C (C) C) =O) [C@@H] (C) C) (=O) N1[C@@H] (C (N[C@H] (C (N[C@@H] (C (N[C@H]2C (=O) N[C@] ([C@H] (CC) C) (C (=O) N[C@H] (C (C) C) C (=O) N[C@@H] (CC3=CC=CC=C3) C (=O) N/C (=C\C) /C (=O) N[C@@H] (C (C) C) C (=O) O[C@@H]2C) [H]) =O) [C@H] (CC) C) =O) CCCN) =O) CCC1

Molecular Formula

C75H124N14O16

Molecular Weight

1477.9

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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