CPAG-1

CPAG-1 is a small molecule activator of the progesterone receptor membrane component 2 (PGRMC2) . It facilitates the delivery of mitochondrially-produced heme to the nucleus via PGRMC2 and activates thermogenesis-related genes like Ucp1 and Pgc-1α in brown adipose tissue (BAT), while reducing lipid accumulation in BAT. Additionally, CPAG-1 lowers fasting blood glucose and insulin levels, improving glucose tolerance and insulin sensitivity. It is applicable for research in type 2 diabetes.