MitoBloCK-1

MitoBloCK-1 is an inhibitor that obstructs the import of substrates reliant on the TIM22 pathway. It acts by preventing substrates from binding to the tim9/10 complex, thereby inhibiting their transport and preventing them from reaching the TIM22 translocase. MitoBloCK-1 impedes the mitochondrial import of TIM22 substrate proteins. Additionally, it hampers the transport of carrier proteins, such as ADP/ATP and phosphate carriers, and also inhibits the translocation of another carrier protein, PiC, along with the outer membrane protein Tom40.