VU6052254

VU6052254, a derivative of VU0467319, is a selective, potent, orally active positive allosteric modulator of the muscarinic M1 acetylcholine receptor (mAChR1) that can cross the blood-brain barrier, with an EC50 value of 59 nM. It shows no activity on M2-5 receptors (EC50 value greater than 30 μM) . VU6052254 enhances memory and reverses scopolamine-induced cognitive deficits, with a minimum effective dose of 1 mg/kg. This compound is applicable in research on neurological disorders such as Alzheimer's disease.