CAII-IN-12

CAII-IN-12 (compound 6c) is a potent and selective inhibitor of carbonic anhydrase (CA) II and VII, with inhibition constants hCA II Ki= 47.8 nM and hCA VII Ki= 3.6 nM, and exhibits antiepileptic activity. It is selective for hCA I with a Ki of 370 nM. In mouse models of epilepsy induced by Pentylenetetrazol and Pilocarpine, CAII-IN-12 demonstrates strong anticonvulsant effects. Additionally, it increases the expression of KCC2 in the hippocampus, maintains neuronal integrity, and reduces mTOR activity. CAII-IN-12 is applicable for epilepsy research.