GPX4-IN-21
GPX4-IN-21 (Compound 4d) is a selective inhibitor of glutathione peroxidase 4 (GPX4) . It induces ferroptosis and decreases the levels of ferroptosis-related proteins SLC7A11, SLC11A2, and GPX4. GPX4-IN-21 also promotes the accumulation of reactive oxygen species (ROS) and malondialdehyde (MDA) . This compound exhibits potent antiproliferative activity against melanoma, with an IC50 value of 9.42 μM in A375 cells. GPX4-IN-21 is applicable in cancer research, particularly for studies on melanoma.
Product Specifications
CAS Number
3014384-72-3
Smiles
O=C (NC1=CC=C2OCC (=O) NC2=C1) C3=CC=CC (=C3) C=4N=NN (C4) C=5C=CC=C (Cl) C5
Molecular Formula
C23H16ClN5O3
Molecular Weight
445.86
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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