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PRT-060318 dihydrochloride

PRT-060318 (PRT318) dihydrochloride is a potent, highly selective tyrosine kinase Syk inhibitor with an IC50 of 3 nM, and is orally bioavailable. It inhibits the activation and migration of B cells in chronic lymphocytic leukemia (CLL) and induces apoptosis. Additionally, PRT-060318 dihydrochloride offers potential therapeutic applications by preventing heparin-induced thrombocytopenia and thrombosis in transgenic mouse models, making it useful in studies of chronic lymphocytic leukemia and thrombosis.

Product Specifications

CAS Number

3032567-93-1

Smiles

NC (C (C (NC1=CC (C) =CC=C1) =N2) =CN=C2N[C@H]3[C@H] (CCCC3) N) =O.Cl.Cl

Molecular Formula

C18H26Cl2N6O

Molecular Weight

413.35

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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