NOSH-aspirin

NOSH-aspirin (NBS-1120) is an orally active hybrid molecule that releases nitric oxide and hydrogen sulfide. It inhibits the proliferation of pancreatic cancer cells and induces apoptosis. In a mouse model of pancreatic cancer, NOSH-aspirin suppresses tumor growth and inhibits NF-κB and FoxM1. Additionally, it alleviates motor deficits and dopaminergic neuronal degeneration in a rat model of Parkinson's disease and reduces neuroinflammation caused by the activation of microglia and astrocytes. NOSH-aspirin is useful for research in cancers such as pancreatic cancer and neurological disorders like Parkinson's disease.