LOXL2/sGC modulator-1

LOXL2/sGC modulator-1 (Compound 11k) is an LOXL2 inhibitor with an IC50 of 0.13 μM and acts as an sGC activator. It shows good selectivity for LOX (IC50 > 45.9 μM) and LOXL3 (IC50 = 1.30 μM) . In the presence of the gGC inhibitor ODQ, it significantly increases intracellular cGMP levels. LOXL2/sGC modulator-1 effectively inhibits hypoxia-induced collagen deposition and cross-linking while promoting vasodilation. This compound is useful for researching pulmonary arterial hypertension.