RMC-9945
RMC-9945 (RM-044) is a KRAS inhibitor that is selective, covalent, and orally active against the RAS (ON) G12D mutation. It enhances the transcriptional activity of β-Catenin/TCF and demonstrates sustained disease control in early liver metastasis models of colorectal cancer.
Product Specifications
CAS Number
2922732-38-3
Smiles
O=C1OCC (C) (C) CC=2C3=CC (=CC=C3N (C2C4=CC (=CN=C4C (OC) C) N5CCN (CC5) C6CC6) CC (F) (F) F) C=7N=C (SC7) CC (NC (=O) C (N8CCC9 (CN (C (=O) C%10N (C) C%10C%11CC%11) CC9) C8) C (C) C) C (=O) N%12NC1CCC%12
Molecular Formula
C60H80F3N11O6S
Molecular Weight
1140.43
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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