Phosphodiesterase-IN-5

Phosphodiesterase-IN-5 is a potent and orally bioavailable selective phosphodiesterase 10A (PDE10A) inhibitor, with an IC50 value of 6.2 nM. It demonstrates over 1612-fold selectivity for other PDE subtypes. By blocking the cAMP/PKA/CREB signaling pathway, it inhibits myofibroblast differentiation and shows significant antifibrotic effects in a Bleomycin (BLM) -induced mouse model of pulmonary fibrosis (PF) . Phosphodiesterase-IN-5 is applicable for pulmonary fibrosis research.