Phosphodiesterase-IN-5
Phosphodiesterase-IN-5 is a potent and orally bioavailable selective phosphodiesterase 10A (PDE10A) inhibitor, with an IC50 value of 6.2 nM. It demonstrates over 1612-fold selectivity for other PDE subtypes. By blocking the cAMP/PKA/CREB signaling pathway, it inhibits myofibroblast differentiation and shows significant antifibrotic effects in a Bleomycin (BLM) -induced mouse model of pulmonary fibrosis (PF) . Phosphodiesterase-IN-5 is applicable for pulmonary fibrosis research.
Product Specifications
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
046762 50 µg
CD3d/CD3 delta, Recombinant, Human, His-Tag discontinued
Sign In for Pricing
View Details NBP2-42656MFV450 0.1 mL
Mouse Monoclonal Signal sequence receptor delta Antibody (26G5) [mFluor Violet 450 SE]
Sign In for Pricing
View Details 
MBS2553054-01 0.01 mg
Recombinant Human Partner of Y14 and Mago/WIBG/PYM Protein (C-6His)
Sign In for Pricing
View Details