PARP1-IN-49

PARP1-IN-49 is a selective inhibitor of PARP1 with an IC50 value of 23.56 nM and a Kd of 17.78 nM. It exhibits higher selectivity for PARP1 over PARP2. By inhibiting PARP1, PARP1-IN-49 induces DNA damage, cell cycle arrest, and apoptosis (apoptosis) . Additionally, it increases intracellular reactive oxygen species (ROS) levels and inhibits cell migration. This compound is applicable in breast and ovarian cancer research.