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SB772077B

SB772077B is a ROCK inhibitor with anti-inflammatory properties. It boosts aqueous humor outflow (OF) by inhibiting the RhoA/ROCK signaling pathway. This compound significantly reduces mRNA levels of β-catenin and protein levels of fibrosis markers such as vinculin, fibronectin, collagen1 A, and vimentin. Additionally, SB772077B exhibits vasodilatory effects, lowering both pulmonary arterial and systemic blood pressure. It is useful for research on glaucoma and pulmonary arterial hypertension.

Product Specifications

CAS Number

785774-34-7

Smiles

C (C) N1C=2C (N=C1C=3C (N) =NON3) =CN=CC2C (=O) N4CC[C@H] (N) C4

Molecular Formula

C15H18N8O2

Molecular Weight

342.36

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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