LP-03

LP-03 is an antibacterial agent that exhibits selective activity against methicillin-resistant Staphylococcus aureus (MRSA) with a minimum inhibitory concentration (MIC) of 6.2 μM. It inhibits biofilm formation but is ineffective at removing established biofilms. LP-03 enhances membrane permeability, disrupting the membrane structure of MRSA cells without causing significant membrane depolarization. It shows no hemolytic toxicity and demonstrates low cytotoxicity to mammalian cells. This compound can be utilized for studying MRSA infections.