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BCL6-760

BCL6-760 is an orally active BCL-6 PROTAC degrader with an EC50 of 0.8 nM. It selectively degrades BCL6 without affecting other CRBN substrates. Significant efficacy was demonstrated by BCL6-760 in an OCI-LY-1 tumor xenograft mouse model. This compound is applicable in diffuse large B-cell lymphoma (DLBCL) research.

Product Specifications

CAS Number

3084696-50-1

Smiles

O=C1NC (=O) C (C2=NN (C=3C=C (C=CC32) N4CCC (N (C5=NC=C (Cl) C (=N5) NC6=CC=C7C (=C6) N (C (=O) N7C) CCC (O) (C) C) C) CC4) C) CC1

Molecular Formula

C36H43ClN10O4

Molecular Weight

715.26

Storage Conditions

-20°C

Notes

For research use only.

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