Aurora A-IN-5

Aurora A-IN-5 is a potent and highly selective Aurora A inhibitor (IC50= 0.02 μM) with 362 times higher selectivity for Aurora A over Aurora B. This selectivity is due to its unique C−H/π interactions, enhanced hydrophobic contacts, open binding pocket, and tighter protein stacking. Aurora A-IN-5 inhibits Aurora A autophosphorylation, thereby suppressing cancer cell proliferation through G2/M phase arrest, triggering apoptosis, and inhibiting colony formation. It also inhibits tumor growth in MDA-MB-231 xenograft mouse models. Aurora A-IN-5 is applicable for research related to breast cancer, cervical cancer, prostate cancer, and lymphoma.