Uperolein

Uperolein is a physalaemin-like endecapeptide, produced in the skin of Uperoleia rugosa and Uperoleia marmorata. Uperolein has a spasmodic effect on both the gastrointestinal tract and longitudinal muscles[1][2][3].

Product Specifications

CAS Number

[55601-63-3]

UNSPSC

12352209

Target

Neurokinin Receptor

Type

Peptides

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/uperolein.html

Solubility

10 mM in DMSO

Smiles

O=C(N(CCC1)[C@@H]1C(N[C@@H](CC(N)=O)C(N[C@@H](C)C(N[C@H](C(N[C@H](C(NCC(N[C@@H](CC(C)C)C(N[C@H](C(N)=O)CCSC)=O)=O)=O)CC(C=C2)=CC=C2O)=O)CC3=CC=CC=C3)=O)=O)=O)[C@H](CC(O)=O)NC([C@H](CCC4)N4C([C@@H](N5)CCC5=O)=O)=O

Molecular Formula

C57H79N13O16S

Molecular Weight

1234.38

References & Citations

[1]Poulter L, et al. Levitide, a neurohormone-like peptide from the skin of Xenopus laevis. Peptide and peptide precursor cDNA sequences. J Biol Chem. 1988 Mar 5;263 (7) :3279-83. |[2]Anastasi A, et al. Structure of uperolein, a physalaemin-like endecapeptide occurring in the skin of Uperoleia rugosa and Uperoleia marmorata. Experientia. 1975 Apr 15;31 (4) :394-5.|[3]Zappia L, et al. Effects of natural analogues of substance P on the motility of human gastrointestinal tract in vitro. J Pharm Pharmacol. 1978 Sep;30 (9) :593-4. |[4]Bertaccini G, et al. Action of some natural peptides on the stomach of the anaesthetized rat. Naunyn Schmiedebergs Arch Pharmacol. 1977 Jun;298 (2) :163-6.