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UM-259

UM-259 is a STING inhibitor with an EC50 of 1.50 μM in THP1-Dual cells expressing wild-type STING. It blocks STING oligomerization and inhibits diABZI-induced phosphorylation of TBK1 and IRF3, thereby suppressing the transcription of IFNβ and IL6, and reducing IFNβ secretion. UM-259 can be used to study STING-dependent inflammation and neurological disorders.

Product Specifications

Storage Conditions

-20°C

Notes

For research use only.

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