EGFR/Cytokine-IN-1

EGFR/Cytokine-IN-1 is an inhibitor targeting EGFR with an IC50 of 0.03 μM, as well as cytokines TNF-α (IC50= 3.1 μM) and IL-6 (IC50= 1.6 μM) . This compound demonstrates significant anticancer activity against both A549 and MCF7 cell lines. It effectively reduces IL-6 and TNF-α levels in A549 cells and exhibits favorable ADMET properties. EGFR/Cytokine-IN-1 is capable of inducing apoptosis in a dose-dependent manner and is applicable in breast and lung cancer research.