Paclitaxel-bromothiophene

Paclitaxel-bromothiophene is a semisynthetic taxane analogue of Paclitaxel. It exhibits potent antiproliferative activity against 4-T1 breast cancer cells, with an IC50 value of 15.18 nM. This compound also shows high binding affinity to C5aR1 (Kd= 19.4 μM) . In 4-T1 breast cancer tumor-bearing mice, Paclitaxel-bromothiophene demonstrates excellent antitumor efficacy. It is applicable for breast cancer research.