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GLPG4471

GLPG4471 is a selective and orally active IRAK4 inhibitor with an IC50 of 1.7 nM. It demonstrates potent inhibitory effects on cytokine secretion (TNFα and IFNα) in both cellular and whole blood phenotypic assays. Additionally, GLPG4471 shows significant activity in a collagen-induced arthritis mouse model and can be utilized for arthritis research.

Product Specifications

CAS Number

2499855-36-4

Smiles

O=C (NC1=CC2=CC (=NN2C=C1OC) CCC (O) (C) C) C3=CC=CN (C3=O) C4CC4

Molecular Formula

C22H26N4O4

Molecular Weight

410.47

Storage Conditions

-20°C

Notes

For research use only.

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