5-HT7/5-HT2A receptor antagonist 1
5-HT7/5-HT2A receptor antagonist 1 is a high-affinity, orally active compound capable of crossing the blood-brain barrier, serving as a ligand for both 5-HT7 and 5-HT2A receptors with a pKi of 8.1 at each receptor. It acts as an antagonist in vitro in 5-HT2A functional assays and as an inverse agonist in 5-HT7 functional assays. This compound blocks hypothermia in rats induced by 5-Carboxamidotryptamine (5-CT) and prevents head twitches in mice caused by 2,5-Dimethoxy-4-iodoamphetamine (DOI) . Additionally, it occupies 5-HT2A receptor binding sites in the frontal cortex of rat brains and is applicable in the study of neurological disorders.
Product Specifications
CAS Number
851375-22-9
Smiles
FC=1C=CC (=CC1) C2=C3C (=NN2C (C) C) CCNCC3
Molecular Formula
C16H20FN3
Molecular Weight
273.36
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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CD93 (Complement Component C1Q Receptor, C1q/MBL/SPA Receptor, C1qR, C1qR(p), C1qRp, CDw93, Complement Component 1 q Subcomponent Receptor 1, Matrix-remodeling-associated Protein 4, C1QR1, MXRA4) (AP)