PARP1-IN-46

PARP1-IN-46 is a potent inhibitor of PARP-1 with an IC50 value of 2.4 nM. It demonstrates significant antiproliferative activity in both rat (C6) and human (U87MG) glioma cells. The compound triggers PARP cleavage, induces DNA damage, and elevates ROS levels. PARP1-IN-46 effectively impedes glioma cell migration, invasion, and colony formation, ultimately inducing apoptosis. It is suitable for research on glioma cells.