PARP1-IN-46
PARP1-IN-46 is a potent inhibitor of PARP-1 with an IC50 value of 2.4 nM. It demonstrates significant antiproliferative activity in both rat (C6) and human (U87MG) glioma cells. The compound triggers PARP cleavage, induces DNA damage, and elevates ROS levels. PARP1-IN-46 effectively impedes glioma cell migration, invasion, and colony formation, ultimately inducing apoptosis. It is suitable for research on glioma cells.
Product Specifications
CAS Number
2505146-00-7
Smiles
O=C1NC=2C (=O) C=3C=CC=CC3C (=O) C2C=4C=C (OC) C=CC14
Molecular Formula
C18H11NO4
Molecular Weight
305.29
Storage Conditions
-20°C
Notes
For research use only.
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