Ranbezolid hydrochloride

Ranbezolid (RBx7644 free base) is an orally effective oxazolidinone antibiotic targeting Gram-positive and Gram-negative anaerobes, such as Staphylococcus aureus, Staphylococcus epidermidis, and Bacteroides fragilis. It inhibits the 50S ribosomal subunit with an IC50 of 17 μM for bacterial ribosomes. Ranbezolid also disrupts cell wall and lipid synthesis. This compound acts rapidly as a bactericidal agent, significantly reducing bacterial load while offering improved cardiovascular safety. Ranbezolid is applicable in research on antibiotics against anaerobic bacteria.