CB1 antagonist 6

CB1 antagonist6 (Compound 11jE2) is an orally active CB1R antagonist with an IC50 value of 23 nM. It significantly reduces food intake and body weight in diet-induced obesity (DIO) mice, improves glucose tolerance and insulin resistance, and lowers serum ALT and AST levels, demonstrating hepatoprotective effects. CB1 antagonist6 is applicable for studies on metabolic syndrome, including obesity and diabetes.