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RPR107393

RPR107393 is an orally active and selective inhibitor of squalene synthase (SQS) . It inhibits squalene synthase in rat liver microsomes with an IC50 of 0.8 nM. By increasing cellular farnesol and its derivatives, RPR107393 suppresses fatty acid biosynthesis, thereby reducing triglyceride synthesis. It also lowers plasma cholesterol in rats and marmosets. RPR107393 is applicable in research related to metabolic diseases, such as hypercholesterolemia, hypertriglyceridemia, and atherosclerosis.

Product Specifications

CAS Number

190841-57-7

Smiles

OC1 (CN2CCC1CC2) C3=CC=C (C4=CC=C5N=CC=CC5=C4) C=C3.Cl.Cl

Molecular Formula

C22H24Cl2N2O

Molecular Weight

403.35

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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