CAII/VII-IN-1

CAII/VII-IN-1 is an orally active inhibitor of hCA II (KI= 12.3 nM) and hCA VII (KI= 22.6 nM), showing no significant activity towards hCA I. In vivo, it demonstrates excellent neuroprotective properties in a Pilocarpine-induced epilepsy model. It upregulates KCC2 and inhibits mTOR, contributing to its neuroprotective effects. CAII/VII-IN-1 exhibits no significant neurotoxicity or changes in liver and kidney function, making it a useful compound for epilepsy research.