CAII/VII-IN-1
CAII/VII-IN-1 is an orally active inhibitor of hCA II (KI= 12.3 nM) and hCA VII (KI= 22.6 nM), showing no significant activity towards hCA I. In vivo, it demonstrates excellent neuroprotective properties in a Pilocarpine-induced epilepsy model. It upregulates KCC2 and inhibits mTOR, contributing to its neuroprotective effects. CAII/VII-IN-1 exhibits no significant neurotoxicity or changes in liver and kidney function, making it a useful compound for epilepsy research.
Product Specifications
CAS Number
3085155-69-4
Smiles
O=C (NN=CC1=CN (N=C1C=2C=CC (Cl) =CC2) C3=CC=C (C=C3) S (=O) (=O) C) C=4N=NN (C5=CC=C (C=C5) S (=O) (=O) N) C4C
Molecular Formula
C27H23ClN8O5S2
Molecular Weight
639.1
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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