PF-06835919

PF-06835919 (Ketohexokinase inhibitor 1) is an inhibitor of ketohexokinase (KHK), with IC50s of 8.4 nM and 66 nM for KHK-C and KHK-A, respectively. PF-06835919 can be used for the study of metabolic disorders driven by the overconsumption of Fructose (HY-N0395) [1][2].

Product Specifications

CAS Number

[2102501-84-6]

Product Name Alternative

Ketohexokinase inhibitor 1

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Ketohexokinase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Purity

99.53

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C[C@H]1[C@@]2(CN(C[C@]12[H])C3=NC(N4[C@H](CC4)C)=NC(C(F)(F)F)=C3)[H])O

Molecular Formula

C16H19F3N4O2

Molecular Weight

356.34

Precautions

P261-P280-P302+P352

References & Citations

[1]SUBSTITUTED 3-AZABICYCLO[3.1.0]HEXANES AS KETOHEXOKINASE INHIBITORS. US 20170183328 A1|[2]Kentaro Futatsugi, et al. Discovery of PF-06835919: A Potent Inhibitor of Ketohexokinase (KHK) for the Treatment of Metabolic Disorders Driven by the Overconsumption of Fructose. J Med Chem. 2020 Nov 25;63 (22) :13546-13560.