ZM484

ZM484 is a potent dual inhibitor of p53-MDM2/TOP1, demonstrating antiproliferative and antitumor activities both in vivo and in vitro. By releasing CPT and an effective p53-MDM2 inhibitor, ZM484 efficiently upregulates p53 and MDM2 proteins while maintaining TOP1 inhibitory activity. It induces cell cycle arrest and apoptosis by modulating the expression of key apoptosis and cell cycle-related proteins (including caspase-3, Bcl-2, and Cyclin B1) . ZM484 is applicable for colorectal cancer research.