DHW-208

PI3K-IN-4 is a potent pan-PI3K inhibitor demonstrating high activity across three PI3K isoforms with picomolar IC50 values. It exhibits excellent inhibitory activity against PI3Kα (IC50 = 0.20 nM), PI3Kβ (IC50 = 2.99 nM), PI3Kδ (IC50 = 0.48 nM), and PI3Kγ (IC50 = 0.58 nM), but shows no significant activity against EGFR. By interfering with the PI3K/Akt signaling pathway, PI3K-IN-4 hinders cancer cell proliferation, blocks colony formation, and induces apoptosis (apoptosis) . This compound is applicable in research related to lung cancer, colon cancer, and breast cancer.