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AMPA receptor modulator-9

AMPA receptor modulator-9 is a selective, orally active positive allosteric modulator of AMPARs, capable of crossing the blood-brain barrier. It selectively enhances AMPAR activity in human and rat models, with an EC2x value of 0.96 μM in rat embryonic cortical primary neurons. The compound upregulates BDNF protein expression in primary rat cortical neuron cultures and enhances AMPA-mediated excitatory postsynaptic responses in rats and mice. AMPA receptor modulator-9 is applicable for cognitive disorder studies.

Product Specifications

CAS Number

1204572-46-2

Smiles

O=S1 (=O) NCN (C2=CC (Cl) =C (Cl) C=C21) C3CC3

Molecular Formula

C10H10Cl2N2O2S

Molecular Weight

293.16

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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