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JNJ-78911118

JNJ-78911118 is a potent, blood-brain barrier-penetrating selective GluN2A antagonist (IC50= 44 nM) . It demonstrates over 200-fold selectivity for GluN1/2B, 2C, and 2D receptors. As a negative allosteric modulator (NAM), JNJ-78911118 significantly reduces the potency of glutamate at GluN1/2A receptors and decreases the efficacy of glycine. It exhibits notable pharmacodynamic effects in vivo and is applicable in depression-related research.

Product Specifications

Storage Conditions

-20°C

Notes

For research use only.

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