SHY-867
SHY-867 is a pan-RAS inhibitor that effectively inhibits the binding of K-Ras protein and other members of the RAS small GTPase superfamily, with an IC50 value ranging from 0.5 to 3 μM. It effectively suppresses the phosphorylation of downstream targets such as MEK, ERK1/2, and AKT. Additionally, SHY-867 inhibits the formation of Ras-GTP active complexes and is applicable for research in pancreatic cancer and non-small cell lung cancer.
Product Specifications
CAS Number
2446484-96-2
Smiles
N (C1=C2C (=C (SC2=NC (=N1) C=3N (C) C=CN3) C=4C=CN (C) N4) C5=CC=CC=C5) [C@H]6C[C@@H] (OC) CC6
Molecular Formula
C26H27N7OS
Molecular Weight
485.61
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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