SHY-867

SHY-867 is a pan-RAS inhibitor that effectively inhibits the binding of K-Ras protein and other members of the RAS small GTPase superfamily, with an IC50 value ranging from 0.5 to 3 μM. It effectively suppresses the phosphorylation of downstream targets such as MEK, ERK1/2, and AKT. Additionally, SHY-867 inhibits the formation of Ras-GTP active complexes and is applicable for research in pancreatic cancer and non-small cell lung cancer.