Tubulin-IN-54

Tubulin-IN-54 is a tubulin inhibitor exhibiting antiproliferative effects against various cancer cell lines. It disrupts microtubule assembly, leading to the breakdown of the microtubule network, inducing G2/M phase cell cycle arrest, and promoting apoptosis in cancer cells. Additionally, Tubulin-IN-54 demonstrates significant antitumor efficacy in mice with PC-3/TxR xenografts. It is applicable in studies of paclitaxel-resistant cancers, such as prostate cancer and melanoma.