DI-1548
DI-1548 is a potent, selective, irreversible covalent inhibitor of DCN1 (IC50 = 4.6 nM) . It efficiently and selectively inhibits the neddylation of Cullin 3 at nanomolar concentrations without significantly affecting the neddylation of other Cullin proteins, such as Cullin 1, 2, 4A, 4B, and 5, and exhibits no cytotoxicity. The covalent bond formation between DI-1548 and DCN1 disrupts the DCN1-UBC12 interaction, leading to the disassembly of the neddylation complex and the subsequent inactivation of CRL3. This process results in the accumulation of NRF2 and the upregulation of its target genes, providing hepatoprotective effects in mouse models. DI-1548 is applicable in studies related to liver injury.
Product Specifications
CAS Number
2247060-97-3
Smiles
C ([C@@H] (C (N[C@H] (CNC (C (CN1CCOCC1) =C) =O) [C@H]2CCCCC2) =O) NC (CC) =O) C=3SC=4C (N3) =CC=C (C (C) C) C4
Molecular Formula
C32H47N5O4S
Molecular Weight
597.82
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Tissue, Section, Human Tumor, Breast Tumor, Medullarycarcinoma of Breast (Paraffin)
Tissue, Section, Human Tumor, Breast Tumor, Medullarycarcinoma of Breast (Paraffin)
