CA IX/GPX4-IN-1

CAIX/GPX4-IN-1 (Compound 22abcb) is a dual inhibitor targeting the activities of CA IX and GPX4. It effectively kills SUM159PT cells (IC50= 416 nM) under hypoxic conditions by inducing ferroptosis. In SUM159PT-CAIX-FL cells, the IC50 for CA IX is 663 nM. This compound significantly inhibits tumor growth and can be reversed by a ferroptosis inhibitor. CAIX/GPX4-IN-1 is applicable in research on cancers such as breast cancer.