SERT/5-HT-IN-1

SERT/5-HT-IN-1 is an orally active, potent dual-target inhibitor of SERT/5-HT3A, with inhibitory concentrations as follows: SERTIC50 = 1.5 nM, NETIC50 = 49 nM, DATIC50 = 91 nM, and 5-HT3AKi = 12 nM. It has an IC50 of 39 nM for 5-HT3A and presents a low risk of hepatic, renal, and cardiac toxicity. This compound is applicable in research related to depressive disorders.