Anti-osteoporosis agent-12

Anti-osteoporosis agent-12 (Compound 18) is an orally active pyrazole-fused betulinic acid derivative that exhibits strong anti-osteoporotic properties. It powerfully inhibits RANKL-induced osteoclastogenesis in RAW264.7 cells, with an IC50 of 7.96 nM. Additionally, Anti-osteoporosis agent-12 dose-dependently improves key micro-CT parameters of bone, reduces serum bone resorption marker levels (CTx), and effectively prevents bone loss induced by ovariectomy. This agent is useful for osteoporosis research.