PI3KC2γ-IN-1

PI3KC2γ-IN-1 (Compound 23) is an orally active and selective inhibitor of PI3KC2γ with an IC50 of 4 nM. It downregulates the Akt2-glycogen synthase (GS) signaling pathway, ultimately inhibiting the conversion of glucose to glycogen and reducing excessive glycogen accumulation in the liver. PI3KC2γ-IN-1 significantly inhibits insulin-induced accumulation of PI (3,4) P2 in primary hepatocytes and HepG2 liver cancer cells. It is useful for researching glycogen storage diseases (GSDs) .