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SIRT2-IN-18

SIRT2-IN-18 (Compound 8) is a potent SIRT2 inhibitor, with IC50 values of 5.3 μM for SmSIRT2 and 12.3 μM for hSIRT2. It demonstrates strong anti-schistosomal activity against Schistosoma mansoni strains from Liberia and Puerto Rico, effectively reducing larval and adult worm pair survival, pairing, and egg production, while exhibiting low cytotoxicity to mammalian cells. Additionally, SIRT2-IN-18 enhances histone H3 hyperacetylation and induces apoptosis through cytochrome c mediation.

Product Specifications

CAS Number

858032-59-4

Smiles

O=C1N=C2OC3=CC=C4C=CC=CC4=C3C=C2C (=O) N1C=5C=CC=CC5

Molecular Formula

C21H12N2O3

Molecular Weight

340.34

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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