SIRT2-IN-18
SIRT2-IN-18 (Compound 8) is a potent SIRT2 inhibitor, with IC50 values of 5.3 μM for SmSIRT2 and 12.3 μM for hSIRT2. It demonstrates strong anti-schistosomal activity against Schistosoma mansoni strains from Liberia and Puerto Rico, effectively reducing larval and adult worm pair survival, pairing, and egg production, while exhibiting low cytotoxicity to mammalian cells. Additionally, SIRT2-IN-18 enhances histone H3 hyperacetylation and induces apoptosis through cytochrome c mediation.
Product Specifications
CAS Number
858032-59-4
Smiles
O=C1N=C2OC3=CC=C4C=CC=CC4=C3C=C2C (=O) N1C=5C=CC=CC5
Molecular Formula
C21H12N2O3
Molecular Weight
340.34
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
TM35150L 100 Reactions
Erwinia amylovora TaqMan PCR Lyophilized Kits
Sign In for Pricing
View Details 
PC0928-100g 100 g
3- (N-morpholino) propane-sulfonic Acid, MOPS, 100g
Sign In for Pricing
View Details 
![CMBL Mouse Monoclonal Antibody [Clone ID: AT2B11]](https://cdn.genprice.uk/products/937/68dd189e061270361e8fd6c5/imageurl/am50020pu-n.webp)
AM50020PU-N 100 µL
CMBL Mouse Monoclonal Antibody [Clone ID: AT2B11]
Sign In for Pricing
View Details 