MAO-A/B-IN-5

MAO-A/B-IN-5 is an orally active inhibitor of MAO-A (IC50 = 73.88 μM) and MAO-B (IC50 = 91.08 μM) . It reverses sodium nitroprusside (SNP) -induced brain lipid peroxidation (IC50 = 130.2 μM) and protein carbonylation (IC50 = 229.8 μM) . In mice, MAO-A/B-IN-5 exhibits dose-dependent and time-dependent antidepressant-like effects. This compound is applicable in depression research.