Tubulin-IN-59

Tubulin-IN-59 (Compound 8g) is an orally effective microtubule (Tubulin) inhibitor. It exhibits potent antiproliferative activity against HCT116 colorectal cancer, HeLa cervical cancer, and HepG2 liver cancer cell lines, with IC50 values ranging from 16-35 nM. Tubulin-IN-59 arrests HeLa cells in the G2/M phase and induces apoptosis. It also demonstrates significant antitumor activity in the HT29 human colon cancer mouse xenograft model. Tubulin-IN-59 is applicable for research on colorectal and cervical cancers.